Apoptosis‐Inducing Factor Mediates Microglial and Neuronal Apoptosis Caused by Pneumococcus
نویسندگان
چکیده
منابع مشابه
Apoptosis-inducing factor mediates microglial and neuronal apoptosis caused by pneumococcus.
Streptococcus pneumoniae is the major cause of bacterial meningitis and it damages the hippocampus by inducing neuronal apoptosis. The blocking of caspases provides only partial protection in experimental meningitis, which suggests that there is an additional apoptotic pathway. A trigger of this pathway is the bacterium itself, as exposure of microglia or neurons to live pneumococci induces rap...
متن کاملMicroglial activation mediates host neuronal survival induced by neural stem cells
The rational of neural stem cells (NSCs) in the therapy of neurological disease is either to replace dead neurons or to improve host neuronal survival, the latter of which has got less attention and the underlying mechanism is as yet little known. Using a transwell co-culture system, we reported that, in organotypic brain slice cultures, NSCs significantly improved host neuronal viability. Inte...
متن کاملThe transcription factor NFAT3 mediates neuronal survival.
Neuronal apoptosis is critical for normal development of the mammalian nervous system and also contributes to the pathogenesis of ischemic and degenerative diseases of the brain. Apoptosis of neurons is tightly regulated by extrinsic signals including growth factors and neuronal activity, but the intracellular mechanisms by which these signals promote neuronal survival are incompletely understo...
متن کاملApoptosis Caused by Chemotherapeutic Inhibition of Nuclear Factor- B Activation
Both the protein kinase C ( / ) inhibitor Go6976 and expression of dominant-negative nuclear factor (NF)B inhibitor kinase mutants: (a) blocked the growth and caused regression of a mammary tumor in syngeneic mice; (b) inhibited epidermal growth factor (EGF)-induced activation, nuclear translocation, and DNA-binding activity of NFB; and (c) caused apoptosis of EGF-stimulated cultured mammary tu...
متن کاملCorrection: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
[This corrects the article DOI: 10.1371/journal.pbio.1002466.].
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2001
ISSN: 0022-1899,1537-6613
DOI: 10.1086/324013